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                        DEVELOPMENT AND LICENSE AGREEMENT


                                 BY AND BETWEEN
                              GILEAD SCIENCES, INC.
                                       AND
                            F. HOFFMANN-LA ROCHE LTD
                                       AND
                             HOFFMANN-LA ROCHE INC.



                               SEPTEMBER 27, 1996

<PAGE>

                                TABLE OF CONTENTS

ARTICLE 1. DEFINITIONS . . . . . . . . . . . . . . . . . . . . . . . .    1

     1.1   "Affiliate" . . . . . . . . . . . . . . . . . . . . . . . .    1
     1.2   "Budget". . . . . . . . . . . . . . . . . . . . . . . . . .    2
     1.3   "Cost of Goods Sold". . . . . . . . . . . . . . . . . . . .    2
     1.4   "Cover" . . . . . . . . . . . . . . . . . . . . . . . . . .    2
     1.5   "Development Costs" . . . . . . . . . . . . . . . . . . . .    2
     1.6   "Development Plan". . . . . . . . . . . . . . . . . . . . .    3
     1.7   "European Union". . . . . . . . . . . . . . . . . . . . . .    3
     1.8   "First Commercial Sale" . . . . . . . . . . . . . . . . . .    3
     1.9   "Generically Equivalent Product". . . . . . . . . . . . . .    3
     1.10  "Gilead Know-How" . . . . . . . . . . . . . . . . . . . . .    3
     1.11  "Gilead Patent Rights". . . . . . . . . . . . . . . . . . .    3
     1.12  "IND" (or "Investigational New Drug Application") . . . . .    3
     1.13  "Joint Patent Rights" . . . . . . . . . . . . . . . . . . .    4
     1.14  "NDA" (or "New Drug Application") . . . . . . . . . . . . .    4
     1.15  "Net Sales" . . . . . . . . . . . . . . . . . . . . . . . .    4
     1.16  "Phase III Clinical Trial". . . . . . . . . . . . . . . . .    4
     1.17  "Product(s)". . . . . . . . . . . . . . . . . . . . . . . .    5
     1.18  "Proprietary Information" . . . . . . . . . . . . . . . . .    5
     1.19  "Roche Know-How". . . . . . . . . . . . . . . . . . . . . .    5
     1.20  "Roche Patent Rights" . . . . . . . . . . . . . . . . . . .    5
     1.21  "Steering Committee". . . . . . . . . . . . . . . . . . . .    5
     1.22  "Third Party" . . . . . . . . . . . . . . . . . . . . . . .    5
     1.23  "Third Party Royalties" . . . . . . . . . . . . . . . . . .    6
     1.24  "Valid Claim" . . . . . . . . . . . . . . . . . . . . . . .    6

ARTICLE 2. GRANT OF RIGHTS . . . . . . . . . . . . . . . . . . . . . .    6

     2.1   License Grant.. . . . . . . . . . . . . . . . . . . . . . .    6
     2.2   Sublicensing. . . . . . . . . . . . . . . . . . . . . . . .    6
     2.3   Right of First Refusal. . . . . . . . . . . . . . . . . . .    6
     2.4   Gilead Sublicenses. . . . . . . . . . . . . . . . . . . . .    7
     2.5   Disclosure of Gilead Know-How.. . . . . . . . . . . . . . .    7
     2.6   Related Technology. . . . . . . . . . . . . . . . . . . . .    7

ARTICLE 3. DEVELOPMENT AND REGULATORY AFFAIRS. . . . . . . . . . . . .    7

     3.1   Steering Committee. . . . . . . . . . . . . . . . . . . . .    7
     3.2   Clinical Development and Regulatory Filings.. . . . . . . .    9


                                       i.
<PAGE>

                                TABLE OF CONTENTS
                                   (CONTINUED)


     3.3   Development Costs.. . . . . . . . . . . . . . . . . . . . .    9
     3.4   Adverse Reactions.. . . . . . . . . . . . . . . . . . . . .   11

ARTICLE 4. DUE DILIGENCE. . . . . . . . . . . . . . . . . . . . . . .    11

     4.1   Due Diligence.. . . . . . . . . . . . . . . . . . . . . . .   11
     4.2   Global Commercial Roll-Out. . . . . . . . . . . . . . . . .   13
     4.3   Commercial Due Diligence. . . . . . . . . . . . . . . . . .   13
     4.4   Reports.. . . . . . . . . . . . . . . . . . . . . . . . . .   13

ARTICLE 5. COMPENSATION. . . . . . . . . . . . . . . . . . . . . . . .   14

     5.1   License Fee . . . . . . . . . . . . . . . . . . . . . . . .   14
     5.2   Milestone Payments. . . . . . . . . . . . . . . . . . . . .   14
     5.3   Royalty Payments; Adjustments.. . . . . . . . . . . . . . .   15
     5.4   Sublicense. . . . . . . . . . . . . . . . . . . . . . . . .   18
     5.5   Payment Structure.. . . . . . . . . . . . . . . . . . . . .   18

ARTICLE 6. MANUFACTURING . . . . . . . . . . . . . . . . . . . . . . .   19

     6.1   Pre-Commercial Manufacturing. . . . . . . . . . . . . . . .   19
     6.2   Commercial Manufacturing. . . . . . . . . . . . . . . . . .   19

ARTICLE 7  MARKETING . . . . . . . . . . . . . . . . . . . . . . . . .   20

     7.1   Pricing.. . . . . . . . . . . . . . . . . . . . . . . . . .   20
     7.2   Use of The Gilead Name. . . . . . . . . . . . . . . . . . .   20

ARTICLE 8. PAYMENTS; RECORDS; AUDIT. . . . . . . . . . . . . . . . . .   20

     8.1   Payment; Report.. . . . . . . . . . . . . . . . . . . . . .   20
     8.2   Exchange Rate; Manner and Place of Payment. . . . . . . . .   20
     8.3   Records and Audit.. . . . . . . . . . . . . . . . . . . . .   21
     8.4   Withholding Taxes.. . . . . . . . . . . . . . . . . . . . .   22

ARTICLE 9. TERM AND TERMINATION. . . . . . . . . . . . . . . . . . . .   22

     9.1   Term. . . . . . . . . . . . . . . . . . . . . . . . . . . .   22
     9.2   Licenses upon Expiration. . . . . . . . . . . . . . . . . .   22
     9.3   Termination for Breach. . . . . . . . . . . . . . . . . . .   23
     9.4   Termination for Gilead's Breach.. . . . . . . . . . . . . .   23
     9.5   Product Reversion.. . . . . . . . . . . . . . . . . . . . .   23
     9.6   Termination by Roche For Convenience. . . . . . . . . . . .   24
     9.7   Survival. . . . . . . . . . . . . . . . . . . . . . . . . .   24


                                       ii.
<PAGE>

                                TABLE OF CONTENTS
                                   (CONTINUED)

ARTICLE 10.  INTELLECTUAL PROPERTY . . . . . . . . . . . . . . . . . .   24

     10.1  Ownership of Inventions.. . . . . . . . . . . . . . . . . .   24
     10.2  Prosecution of Patents. . . . . . . . . . . . . . . . . . .   24
     10.3  Infringement of Patents by Third Parties. . . . . . . . . .   26
     10.4  Infringement of Third Party Rights. . . . . . . . . . . . .   27
     10.5  Patent Marking. . . . . . . . . . . . . . . . . . . . . . .   28

ARTICLE 11.  INDEMNIFICATION . . . . . . . . . . . . . . . . . . . . .   28

     11.1  Indemnification by Gilead.. . . . . . . . . . . . . . . . .   28
     11.2  Indemnification by Roche. . . . . . . . . . . . . . . . . .   28
     11.3  Mechanics.. . . . . . . . . . . . . . . . . . . . . . . . .   28
     11.4  Insurance Coverage. . . . . . . . . . . . . . . . . . . . .   29

ARTICLE 12.  CONFIDENTIALITY . . . . . . . . . . . . . . . . . . . . .   30

     12.1  Proprietary Information; Exceptions.. . . . . . . . . . . .   30
     12.2  Authorized Disclosure . . . . . . . . . . . . . . . . . . .   31
     12.3  Return of Proprietary Information.. . . . . . . . . . . . .   31
     12.4  Publications. . . . . . . . . . . . . . . . . . . . . . . .   32

ARTICLE 13.  REPRESENTATIONS AND WARRANTIES. . . . . . . . . . . . . .   32

     13.1  Mutual Representations and Warranties.. . . . . . . . . . .   32
     13.2  Gilead Representations and Warranties.. . . . . . . . . . .   32
     13.3  No Other Representations. . . . . . . . . . . . . . . . . .   33

ARTICLE 14.  DISPUTE RESOLUTIONS; VENUE AND GOVERNING LAW. . . . . . .   33

     14.1  Disputes. . . . . . . . . . . . . . . . . . . . . . . . . .   33
     14.2  Alternative Dispute Resolution. . . . . . . . . . . . . . .   34
     14.3  Arbitration Procedure.. . . . . . . . . . . . . . . . . . .   34
     14.4  Judicial Enforcement. . . . . . . . . . . . . . . . . . . .   36
     14.5  Governing Law.. . . . . . . . . . . . . . . . . . . . . . .   36

ARTICLE 15.  MISCELLANEOUS . . . . . . . . . . . . . . . . . . . . . .   36

     15.1  Agency. . . . . . . . . . . . . . . . . . . . . . . . . . .   36
     15.2  Assignment. . . . . . . . . . . . . . . . . . . . . . . . .   36
     15.3  Amendment.. . . . . . . . . . . . . . . . . . . . . . . . .   36
     15.4  Notices.. . . . . . . . . . . . . . . . . . . . . . . . . .   36
     15.5  Force Majeure.. . . . . . . . . . . . . . . . . . . . . . .   37
     15.6  Affiliates. . . . . . . . . . . . . . . . . . . . . . . . .   38


                                      iii.

<PAGE>


                                TABLE OF CONTENTS
                                   (CONTINUED)

     15.7  Export Control. . . . . . . . . . . . . . . . . . . . . . .   38
     15.8  Severability. . . . . . . . . . . . . . . . . . . . . . . .   38
     15.9  Cumulative Rights.. . . . . . . . . . . . . . . . . . . . .   38
     15.10 Waiver. . . . . . . . . . . . . . . . . . . . . . . . . . .   38
     15.11 Entire Agreement. . . . . . . . . . . . . . . . . . . . . .   38




                                       iv.
<PAGE>

                        DEVELOPMENT AND LICENSE AGREEMENT


     THIS DEVELOPMENT AND LICENSE AGREEMENT (the "AGREEMENT"), dated as of
September 27, 1996 (the "EFFECTIVE DATE"), is made by and between GILEAD
SCIENCES, INC., a Delaware corporation ("GILEAD"), on the one hand, and F.
HOFFMANN-LA ROCHE LTD, a corporation organized under the laws of Switzerland,
and HOFFMANN-LA ROCHE INC, a corporation organized under the laws of New Jersey,
on the other hand (collectively, "ROCHE").

                                   BACKGROUND

     WHEREAS, Gilead has discovered and is developing a series of proprietary
compounds which act as influenza neuraminidase inhibitors and may be effective
in the prevention and treatment of influenza; and

     WHEREAS, Roche, through its divisions and/or subsidiaries, is engaged in
the development, production and commercialization of pharmaceuticals, but prior
to the date of this Agreement has not established a research program in the area
of influenza neuraminidase inhibition or discovered compounds which have such
effect; and

     WHEREAS, Gilead and Roche desire to enter into a development and license
agreement for the worldwide development and marketing of influenza neuraminidase
inhibitors for the prevention and treatment of influenza.

     NOW, THEREFORE, in consideration of the foregoing premises and the
covenants and obligations set forth in this Agreement, the parties hereby agree
as follows:

                                    ARTICLE 1

                                   DEFINITIONS
     As used herein, the following terms will have the following meanings:

     1.1  "AFFILIATE" means any entity that directly or indirectly Owns, is
Owned by or is under common Ownership with, a party to this Agreement, where
"Own" or "Ownership" means direct or indirect possession of at least fifty
percent (50%) of the outstanding voting securities of a corporation or a
comparable ownership in any other type of entity, provided, however, that if the
law of the jurisdiction in which such entity operates does not allow fifty
percent (50%) or greater ownership by a party to this Agreement, such ownership
interest shall be at least forty percent (40%).  The term Affiliate shall not
include Genentech, Inc., 460 Point San Bruno Boulevard, South San


                                       1.
<PAGE>

Francisco, California, prior to the time Roche delivers notice to Gilead
designating Genentech as its Affiliate.

     1.2  "BUDGET" means the annual budget approved by the parties from time to
time pursuant to Section 3.3(d).

     1.3  "COST OF GOODS SOLD" means the manufacturing cost of Product sold by
Roche, its Affiliates and sublicensees, calculated in accordance with reasonable
cost accounting methods of such parties, provided that such methods comply with
generally accepted accounting principles and the further provisions of this
Section 1.3.  Cost of Goods Sold shall consist of direct labor and materials and
a reasonable allocation of indirect labor, facilities expense (including
depreciation over the expected life of the buildings and equipment), and
administration costs.  Cost of Goods Sold shall exclude costs associated with
process development, initial Product batches for regulatory approval, plant
start-up costs, excess capacity, Third Party royalties, or any costs for which
provision has been made in the definition of Net Sales.  In the event of any
transfer of Product among Roche, its Affiliates or sublicensees, the Cost of
Goods Sold shall exclude any profit or other mark-up by any such parties.

     1.4  "COVER" (including variations thereof such as "Covered," "Coverage,"
or "Covering") shall mean that the manufacture, use or sale of a particular
product would infringe a Valid Claim of an issued patent in the absence of
rights under such patent.  The determination of whether a product is Covered by
particular patent rights shall be made on a country by country basis.

     1.5  "DEVELOPMENT COSTS" mean the costs incurred by Gilead or for its
account after the Effective Date which are consistent with the Development Plan
and are specifically attributable to the development of Products.  Such costs
shall mean the direct costs and the indirect costs of all Gilead development
personnel and any third party costs, all of them incurred to further the Product
development program.  Indirect costs related to the Development Plan shall
include but not be limited to salaries, employee benefits, use of facilities and
equipment, personnel, travel materials and supplies, which shall be absorbed
into the Development Costs based on generally accepted accounting principles and
methods approved by Roche, such approval not to be unreasonably withheld.


                                       2.
<PAGE>

     1.6  "DEVELOPMENT PLAN" means the plan for the development of Products
approved from time to time pursuant to Section 3.3.  The initial Development
Plan, reflecting the mutual objectives of the parties with respect to the
sequence of events leading up to the filing of regulatory submissions, has been
agreed to by the parties as of the Effective Date.

     1.7  "EUROPEAN UNION" or "EU" means the following countries:  Austria,
Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, The
Netherlands, Portugal, Spain, Sweden, and the United Kingdom.

     1.8  "FIRST COMMERCIAL SALE" means the first sale, in any particular
country, by Roche or its Affiliates or sublicensees of Product for use by the
general public after required marketing and pricing approval has been granted by
the governing health authority of that country.

     1.9  "GENERICALLY EQUIVALENT PRODUCT" shall mean a product marketed by a
Third Party, not under license from Roche, which contains as an active
ingredient an influenza neuraminidase inhibitor the composition of matter of
which is within the scope of a Gilead Patent Right or a Joint Patent Right.

     1.10 "GILEAD KNOW-HOW" means all proprietary inventions, technology, trade
secrets, clinical and preclinical results, and any physical, chemical or
biological material, or other information excluding Gilead Patent Rights and
Joint Patent Rights, owned or acquired with right to sublicense during the term
of this Agreement by Gilead or any Affiliate of Gilead, which are necessary or
useful to Roche in the development, formulation, manufacture, use or sale of
Products.

     1.11 "GILEAD PATENT RIGHTS" mean the rights under patents and patent
applications, both foreign and domestic, which (a) Cover an influenza
neuraminidase inhibitor, or its manufacture, formulation or use, including
intermediates for the manufacture or use thereof, (b) are based on an invention
made at any time prior to the fifth anniversary of the Effective Date and (c)
are owned by or licensed to Gilead or any Gilead Affiliate with the right to
sublicense.  Notwithstanding the foregoing, Gilead Patent Rights shall exclude
Joint Patent Rights but shall include "Gilead Patents," which are defined as
those patents and patent applications owned by or licensed to Gilead or any
Gilead Affiliate with the right to sublicense that are encompassed within Gilead
Patent Rights.  Set forth as Exhibit A is a list of the Gilead Patents as of the
Effective Date.  Such Exhibit shall be updated no more frequently than annually
upon Roche's request.

     1.12 "IND" (OR "INVESTIGATIONAL NEW DRUG APPLICATION") means an application
as defined in the United States Food, Drug and Cosmetic Act and applicable
regulations promulgated thereunder to the United States Food and Drug
Administration (the "FDA") or the equivalent application to the equivalent
agency in any other country or


                                       3.
<PAGE>

group of countries, the filing of which is necessary to commence clinical
testing of Products in humans.

     1.13 "JOINT PATENT RIGHTS" mean the rights under patents and patent
applications, both foreign and domestic, which (a) Cover an influenza
neuraminidase inhibitor, or its manufacturing formulation or use, including
intermediates for the manufacture or use thereof, (b) are based on an invention
made at any time prior to the fifth anniversary of the Effective Date, and (c)
are owned jointly by Gilead and Roche.  Exhibit A shall be amended to include
Joint Patents when such patent applications are first filed.

     1.14 "NDA" (OR "NEW DRUG APPLICATION") means an application as defined in
the United States Food, Drug and Cosmetic Act and applicable regulations
promulgated thereunder to the United States FDA or the equivalent application to
the equivalent agency in any other country or group of countries, the filing of
which is necessary to commence commercial sale of Products.

     1.15 "NET SALES" means the gross sales invoiced by Roche, its Affiliates or
sublicensees for Product to Third Parties other than sublicensees, less
deductions of returns (including withdrawals and recalls), rebates (price
reductions, including Medicaid and similar types of rebates, e.g. chargebacks),
volume (quantity) discounts, discounts granted at the time of invoicing, sales
taxes and other taxes directly linked to and included in the gross sales amount
as computed on a product by product basis for the countries concerned
(hereinafter referred to as "Adjusted Gross Sales").


     From the Adjusted Gross Sales there shall be a lump sum deduction of 
[        ] for those sales-related deductions which are not 
accounted for on a product by product basis (e.g., outward freights, 
transportation insurance, packaging materials for dispatch of goods, custom 
duties, discounts granted later than at the time of invoicing, cash discounts 
and other direct sales expenses).

     In the case of Products being sold as part of a combination product
containing the Product and one or more other therapeutically active ingredients,
the parties shall negotiate an appropriate royalty adjustment to reflect the
relative significance of each such ingredient, based on the estimated fair
market value of each such therapeutically active ingredient.

     Notwithstanding the foregoing, amounts received by Roche or its Affiliates
or sublicensees for the sale of Licensed Products among Roche and its Affiliates
or sublicensees for resale shall not be included in the computation of Net Sales
hereunder.

     1.16 "PHASE III CLINICAL TRIAL" means any clinical trial primarily designed
to serve as a pivotal, well-controlled study upon which approval of an NDA will
be based,


                      [*] CONFIDENTIAL TREATMENT REQUESTED

                                       4.
<PAGE>

including such a study referred to or denominated as a Phase II/III study in the
United States or the equivalent elsewhere.

     1.17 "PRODUCT(S)" means any pharmaceutical product containing an influenza
neuraminidase inhibitor Covered by a Gilead Patent Right, a Roche Patent Right
or a Joint Patent Right.

     1.18 "PROPRIETARY INFORMATION" means, subject to the limitations set forth
in Section 12.1 hereof, all information disclosed by a party hereto to the other
party pursuant to this Agreement.  In particular, Proprietary Information shall
be deemed to include, but is not limited to, information relating to research
and development programs and results, therapeutic candidates and products,
clinical and preclinical data, trade secrets, business strategy, patent
applications, licenses, suppliers, manufacturers, product and marketing
strategy, customers, market data, personnel and consultants.

     1.19 "ROCHE KNOW-HOW" means all proprietary inventions, technology, trade
secrets, clinical and preclinical results, and any physical, chemical or
biological material, or other information excluding Roche Patent Rights and
Joint Patent Rights, owned or acquired with right to sublicense during the term
of this Agreement by Roche or any Affiliate of Roche, which are necessary or
useful to Roche in the development, formulation, manufacture, use or sale of
Products.

     1.20 "ROCHE PATENT RIGHTS" means the rights under patents and patent
applications, both foreign and domestic, which (a) Cover an influenza
neuraminidase inhibitor, or its manufacture, formulation or use, including
intermediates for the manufacture or use thereof, (b) are based on an invention
made at any time prior to the fifth anniversary of the Effective Date, and (c)
are owned by or licensed to Roche or any Roche Affiliate, with the right to
sublicense.  Notwithstanding the foregoing, Roche Patent Rights shall exclude
Joint Patent Rights, but shall include "Roche Patents," which are defined as
those patents and patent applications owned by or licensed to Roche or any Roche
Affiliate with the right to sublicense that are encompassed within Roche Patent
Rights.  Exhibit A shall be amended to include Roche Patents when such patent
applications are first filed.  Such Exhibit shall be updated no more frequently
than annually upon Gilead's request.

     1.21 "STEERING COMMITTEE" means that committee comprised of an equal number
of representatives of Gilead and Roche, but not less than two (2)
representatives from each company, which shall have the responsibilities set
forth in Section 3.1 and elsewhere in this Agreement.

     1.22 "THIRD PARTY" means any person or entity other than Gilead, Roche or
an Affiliate of either party hereto.


                                       5.
<PAGE>

     1.23 "THIRD PARTY ROYALTIES" means any royalties or license fees owing to a
Third Party attributable to the manufacture, use or sale of Products and in
consideration of a license under any patent which such Product would otherwise
infringe.

     1.24 "VALID CLAIM" means a claim in the Gilead Patent Rights, the Roche
Patent Rights, or the Joint Patent Rights, which has not been disclaimed or held
invalid by a decision beyond the right of review or otherwise has been finally
determined by a court of competent jurisdiction to be unenforceable.

                                    ARTICLE 2

                                 GRANT OF RIGHTS

     2.1  LICENSE GRANT.  Subject to the terms of this Agreement, Gilead hereby
grants to Roche and its Affiliates a sole and exclusive, worldwide license under
the Gilead Patent Rights, Gilead's interest in the Joint Patent Rights, and the
Gilead Know-How only for the manufacture, importation, use, sale and offer for
sale of Products for any and all uses.  Roche agrees that the Gilead Patents and
the Gilead Know-How will not be used for any other purpose.

     2.2  SUBLICENSING.  Except as otherwise provided in Section 2.3 below,
Roche shall have the right to sublicense the rights granted under Section 2.1 to
Third Parties.  If Roche grants a sublicense, all of the terms and conditions of
this Agreement shall apply to the sublicensee to the same extent as they apply
to Roche for all purposes of this Agreement.  Roche assumes full responsibility
for the performance of all obligations so imposed on such sublicensee and will
itself pay and account to Gilead for all royalties due under this Agreement by
reason of the operations of any such sublicensee.

     2.3  RIGHT OF FIRST REFUSAL.  In the event Roche desires to sublicense 
the rights granted pursuant to Section 2.1 above to any Third Party for 
commercialization in any of the following countries:  the [                  ]
Roche shall first present an offer to Gilead for such rights.  Gilead and 
Roche shall negotiate such offer in good faith for at least [                ]
from the date the offer is received by Gilead; PROVIDED, HOWEVER, that Roche 
shall not have an obligation to engage in such negotiations with respect to 
countries where Gilead has not established a sales force or committed to do 
so prior to the anticipated launch of the Product in such country.  If, at 
the end of such [            ] period, the parties have been unable to 
reach agreement on the essential terms of an agreement granting Product 
rights in such country or countries to Gilead, Roche shall be free to offer 
the rights to Products in such country or countries to any Third Party; 
provided, however, that Roche shall not make an offer more favorable to any 
such Third Party than the offer last made to Gilead by Roche without first 
giving Gilead at least [               ] to consider and accept such more 
favorable offer.

                      [*] CONFIDENTIAL TREATMENT REQUESTED

                                       6.

<PAGE>

     2.4  GILEAD SUBLICENSES.  It is the understanding of the parties that the
license granted to Roche in Section 2.1 includes any future technology which
Gilead may acquire by license, with the right to sublicense, which is relevant
to the activities defined in Section 2.1.  In the event Gilead obtains under
license from a Third Party technology the subject matter of which falls under
the license granted herein, Gilead shall promptly advise Roche of such license
and the terms which would be applicable to Roche in the event a sublicense is
granted hereunder.  Roche may decline to accept the sublicense in question.  If,
following such disclosure, Roche elects to receive such sublicense, then such
technology shall automatically be sublicensed to Roche hereunder without further
consideration to Gilead.  In the event of any such sublicense, the terms of the
agreement between Gilead and its licensor shall govern in the event of any
inconsistency between such Third Party license agreement and this Agreement, and
the rights granted to Roche herein shall be explicitly subject to such Third
Party license agreement.

     2.5  DISCLOSURE OF GILEAD KNOW-HOW.  Following the Effective Date and
through the term of this Agreement, Gilead shall make available to Roche,
subject to the terms of this Agreement, all Gilead Know-How.

     2.6  RELATED TECHNOLOGY.  Roche acknowledges that in consideration of the
collaboration established hereby and the enabling nature of the work previously
done by Gilead, any influenza neuraminidase inhibitors as to which Roche or its
Affiliates acquires rights prior to the fifth anniversary of the Effective Date,
whether by reason of their own efforts or under contract from Third Parties,
shall be included within the definition of Products under this Agreement,
subject to the terms and conditions hereof.  Similarly, Gilead acknowledges that
its license to Roche hereunder covers all of the influenza neuraminidase
inhibitors as to which it has rights or acquires rights prior to the fifth
anniversary of the Effective Date.

                                    ARTICLE 3

                       DEVELOPMENT AND REGULATORY AFFAIRS

     3.1  STEERING COMMITTEE.

               (a)  STEERING COMMITTEE MEMBERSHIP AND GOVERNANCE.  The parties
shall establish a Steering Committee to coordinate the activities of the parties
with respect to Products.  The Steering Committee in turn may establish such
working groups or other mechanisms as it desires to achieve this result.  Except
to the extent otherwise provided in this Agreement, the responsibility of the
Steering Committee for each Product in each country shall terminate following
the initial commercial launch of such Product in such country.  The Steering
Committee shall consist of an equal number of representatives of each party,
which shall be at least two (2).  The size of the Steering Committee may be
changed by agreement of the parties.  Each party shall within thirty


                                       7.
<PAGE>

(30) days after the Effective Date select its initial members of the Steering
Committee.  Each party may select additional representatives to replace the
initial Steering Committee members selected by such party as necessary during
the term of the Agreement, and may have other representatives attend meetings of
the Steering Committee in addition to the members of the committee.  Any
Steering Committee members selected by one party shall be subject to the
reasonable approval of the other party.  The Chairperson of the Steering
Committee shall alternate annually between a representative of Gilead and a
representative of Roche, with the initial Chairperson of the Steering Committee
being appointed by Roche.  The Chairperson of the Steering Committee shall be
responsible for providing an agenda for each meeting of the committee at least
ten (10) days in advance of such meeting and shall prepare written minutes of
all committee meetings in reasonable detail.  The Chairperson shall distribute
such minutes to all members of the Steering Committee within twenty (20) days
after the relevant meeting.  The Steering Committee shall attempt to operate by
consensus, and any issues that the Steering Committee is unable to resolve by
consensus shall be submitted for resolution pursuant to Article 14 below.


               (b)  STEERING COMMITTEE MEETINGS AND RESPONSIBILITIES.  The
Steering Committee shall meet at least two (2) times per year until the First
Commercial Sale of a Product in any country, and thereafter as appropriate for
the continued development and registration of Products.  In addition, either
party may request additional meetings as reasonably required.  The Steering
Committee shall be responsible for overseeing and monitoring the implementation
of the Development Plan and the Budget.  In particular, the Steering Committee
will review and approve each annual Budget pursuant to Section 3.3.  The
Steering Committee shall also monitor the allocation of research and development
work between the parties and shall recommend changes as necessary.  The parties
shall report to the Steering Committee on all significant clinical and
regulatory issues relating to Products, and the Steering Committee shall make
recommendations and provide strategic guidance with respect to such issues.  The
Steering Committee shall meet to review and approve a global clinical trial
program prior to the conduct of any clinical trials, and shall review and
approve the plans for any individual clinical trial of Product in advance of the
anticipated commencement date thereof.  Neither party shall commence any
clinical trial of a Product until the Steering Committee has approved the plans
therefor, PROVIDED, HOWEVER, that such requirement for prior approval shall not
apply to post-marketing clinical trials which are not directed towards a change
in the labeling of the Product.  In addition to its responsibilities related to
research and development, the Steering Committee shall oversee manufacturing
activities related to the Products and plans for the initial commercial launch
and country-by-country roll out of Products, and Roche shall report to the
Steering Committee in reasonable detail regarding its current and planned
activities in these areas.


                                       8.
<PAGE>

     3.2  CLINICAL DEVELOPMENT AND REGULATORY FILINGS.

               (a)  CLINICAL DEVELOPMENT.  The collaborative clinical
development program will follow the most expeditious path to achieve global
registration of Products with both parties playing a significant role in the
execution of clinical development activities.  [


            ]  Both parties will contribute to the conduct of clinical trials
as necessary to support the global program.  The final distribution of
responsibility will be the decision of the Steering Committee.

               (b)  REGULATORY FILINGS.  Gilead shall prepare and file in its 
own name the IND for Products in the United States. [

                  ]  The particular responsibility for filings, 
interactions with regulatory authorities and the appropriate time for 
transfer of regulatory responsibility to Roche will be decided by the 
Steering Committee.  In any event, prior to the transfer of the IND in the 
United States, Roche shall receive copies of all material correspondence with 
the FDA and shall have the right to be present at all meetings with the FDA 
related to Products.  Beginning at the time of transfer of ownership of the 
IND to Roche, Roche shall be primarily responsible with Gilead's assistance 
for all regulatory affairs in the United States related to Products.  In 
addition, Gilead shall either transfer ownership of, or provide Roche with 
letters of access to, any drug master files or other regulatory dossiers 
containing information necessary or useful to Roche in connection with its 
regulatory filings for Product, with the choice between transfer or providing 
letters of access to be made in the discretion of Gilead. In all countries, 
Gilead shall be entitled to receive copies of material correspondence with 
regulatory authorities, including filings made by Roche, with respect to 
Products, and Gilead shall have the right to be present at all meetings with 
regulatory authorities related to Products.

               (c)  DILIGENCE.  Roche and Gilead will each diligently carry out
the global development of Products as provided in this Section 3.2, subject to
the Budgets approved under Section 3.3(d).  Without limitation of the foregoing,
such efforts shall include the assignment of appropriate personnel and the
allocation of sufficient resources to carry out such party's responsibilities
under the Development Plan.

     3.3  DEVELOPMENT COSTS.

               (a)  GENERAL.  Roche shall pay all its own research and
development expenses in carrying out the Development Plan, as modified from time
to time by the Steering Committee, and shall reimburse Gilead for all its
Development Costs incurred pursuant to the Development Plan and the Budget in
effect at the time.


                      [*] CONFIDENTIAL TREATMENT REQUESTED

                                       9.
<PAGE>

               (b)  AUDIT RIGHTS.  Gilead shall keep complete and accurate
records pertaining to the Development Costs incurred pursuant to this Agreement
in sufficient detail to permit Roche to confirm the accuracy of such Costs.  At
Roche's request, Gilead will cause its independent certified public accountants
to prepare abstracts of Gilead's relevant business records for review by Roche's
independent certified public accountants.  If, based on a review of such
abstracts, Roche reasonably believes that a full audit of said business records
would be necessary for the confirmation of the accuracy of the Development
Costs, Roche's independent certified public accountants shall have full access
to review all work papers and supporting documents pertinent to such abstracts,
and shall have the right to discuss such documentation with Gilead's independent
certified public accountants. [









                                               ]  Such audit rights may be
exercised no more often than once a year, within three (3) years after the
period to which such records relate, upon notice to Gilead and during normal
business hours. Roche will bear the full cost of such audit unless such audit
discloses an overpayment of Development Costs by Roche of more than five percent
(5%) from the amount due. Gilead shall promptly refund any such overpayment. The
terms of this Section 3.3 (b) shall survive any termination or expiration of
this Agreement for a period of three (3) years.

                (c) REIMBURSEMENT OF PRIOR RESEARCH EXPENSES.  In addition to
the payment of Development Costs as provided herein, Roche shall, within ten
(10) days after the Effective Date, pay to Gilead the amount of [
                 ] as reimbursement for research and preclinical development
expenses incurred by Gilead with respect to Products prior to the Effective
Date.  Such payment shall be nonaccountable, nonrefundable and noncreditable.

               (d)  BUDGET.  It is agreed between the parties that as of the
Effective Date, the amount of [              ] is the estimated budget for
reimbursement to Gilead for its internal research and development efforts under
the Development Plan during a period of [                                ]
following the Effective Date.  In addition, Gilead's external expenses for such
research and development will be reimbursed pursuant to the Budget and in
accordance with Section 3.3(e).  Within forty-five (45) days following the
Effective Date, the Steering Committee shall adopt a Budget for all research and
development activities anticipated for the period from the Effective


                      [*] CONFIDENTIAL TREATMENT REQUESTED

                                       10.
<PAGE>

Date through December 31, 1997.  The Budget approved by the Steering 
Committee will replace the estimated budget for Gilead's internal expenses 
referred to above.  On or before October 1, 1997, and not later than October 
1 of each subsequent calendar year during the term of this Agreement, the 
Steering Committee shall approve annual budgets for all research and 
development activities scheduled for the following calendar year; such annual 
budgets shall be consistent with the Development Plan, as modified from time 
to time by the Steering Committee.  Upon approval, annual budgets shall be 
the Budget then in effect. 

               (e)  PAYMENTS TO GILEAD; RECONCILIATION.  Roche shall pay to 
Gilead the amount budgeted for Gilead's Development Costs for each calendar 
quarter on or before the first day of such calendar quarter within 
[              ] after receipt of an invoice from Gilead.  Within 
[                ] following the end of each such calendar quarter, Gilead 
shall provide an accounting to Roche of the Development Costs actually 
incurred by it during such quarter (the "Actual Costs"), but for the first 
three quarters of each calendar year such reports shall be for informational 
purposes only and Roche's payment of Development Costs shall continue to be 
made in accordance with the Budget for such year then in effect.  At the end 
of each calendar year, the parties shall reconcile any difference between the 
amounts paid to Gilead for Development Costs and Gilead's Actual Costs for 
such year.  If the amounts paid to Gilead for Development Costs exceed its 
Actual Costs during such year, the amount of the excess shall be refunded or 
credited to Roche.  If Gilead's Actual Costs during the year exceeded the 
amounts paid by Roche for Development Costs during such year, the excess 
shall be paid by Roche as a supplemental payment if Roche approves such 
excess amount, which approval shall not be unreasonably withheld.

     3.4  ADVERSE REACTIONS.  Roche shall be responsible for reporting to the
appropriate regulatory authorities all adverse events related to the use of
Product worldwide, except that prior to the time Gilead transfers ownership of
the IND to Roche as provided in Section 3.2(b), Gilead shall be responsible for
the reporting of such adverse events in the U.S.  Adverse events related to the
use of Product worldwide shall be recorded in a single database, and the parties
will coordinate their efforts to assure that all adverse events are reported
properly.

                                    ARTICLE 4

                                  DUE DILIGENCE

     4.1  DUE DILIGENCE.  Roche shall devote its Best Efforts to commercialize
Product in substantially all markets in the world.  As used herein, "Best
Efforts" shall mean that Roche is performing its obligations in a sustained
manner consistent with the efforts major pharmaceutical companies devote to
significant general practice products of


                      [*] CONFIDENTIAL TREATMENT REQUESTED

                                       11.
<PAGE>

similar market potential derived from internal research programs.  Upon gaining
the necessary regulatory, pricing and reimbursement approvals, Roche and/or its
sublicensees shall use its Best Efforts to promote and market the Product in all
significant markets.  Any sublicense of marketing rights by Roche shall include
a covenant for such sublicensee to use Best Efforts to maintain and increase
sales of the Product in each country covered by the sublicense.


                                       12.
<PAGE>

     4.2  GLOBAL COMMERCIAL ROLL-OUT.  Roche shall endeavor to obtain prompt 
approval for the sale of Product in substantially all countries of the world, 
once such approval has been obtained in the United States and Europe.  In 
particular, subject to the exception set forth below, Gilead shall have the 
right to terminate Roche's license to any particular Product in any country 
of the world [


                                             ] (For such purpose, "approval" 
shall mean approval as to safety and efficacy but not pricing approval if 
separately required.)  Gilead shall not have the right to terminate Roche's 
license in any particular country where Roche can show that either (a) it 
used Best Efforts to achieve such registration within the specified time 
period, or (b) it is not reasonable to commercialize the Product in the 
country in question (for example, because of pricing).  If Roche believes 
that either of the conditions set forth in the previous sentence apply, it 
shall so notify the Steering Committee at least one year prior to the 
expiration of the [         ] time period referred to above, and shall 
explain its reasons.  If Roche loses Product rights in any country pursuant 
to this Section 4.2, Gilead shall obtain rights thereto as provided in 
Section 9.5. [

                                                     ]

     4.3  COMMERCIAL DUE DILIGENCE.  If, regardless of whether Roche 
exercises Best Efforts, annual Net Sales of Products worldwide are less than 
[          ] by the conclusion of the [                 ] following the date 
of First Commercial Sale of a Product in the U.S. or any country of the EU, 
then the parties agree to meet and confer in good faith regarding the most 
appropriate corrective actions to take in significant markets.  The following 
factors shall be considered by the parties in determining the most 
appropriate course of action: (i) Roche's competitive position, including 
promotional spending levels, sizes of field sales forces and market 
development expenditures, relative to competitive products; (ii) cost of 
goods sold; (iii) policy of health authorities on prophylaxis of influenza 
and (iv) Gilead's interest in, and ability to increase revenues by, assuming 
all rights to the Product.  In the event the parties agree that the rights to 
the Product shall revert to Gilead, the parties shall thereupon agree on 
appropriate commercial terms for the reversion of such rights.

     4.4  REPORTS.  Roche shall provide annual reports to Gilead as follows:
(i) by February 1 of each year concerning its marketing activities relating to
Products for the previous year, and (ii) by November 30 of each year concerning
its contemplated marketing activities relating to Products for the subsequent
year.  In particular, such reports shall include specific budgets and timetables
for activities in the [
                        ], the positioning of the Product, competitive
issues,


                      [*] CONFIDENTIAL TREATMENT REQUESTED

                                       13.
<PAGE>

and Roche's primary sales and marketing objectives with respect to Products in
such countries.

                                    ARTICLE 5

                                  COMPENSATION

     5.1  LICENSE FEE.  Roche shall pay to Gilead a license fee of [
              ] within ten (10) days following the Effective Date.  Such
license fee shall be nonrefundable and noncreditable.

     5.2  MILESTONE PAYMENTS.  Roche shall pay to Gilead the following
nonrefundable, noncreditable amounts within thirty (30) days of achievement of
the milestone events set forth below for any Product(1):

<TABLE>
<CAPTION>


                                                  U.S.                EU                  JAPAN
<S>                                             <C>                <C>                  <C>
[







                                                                                                     ]

</TABLE>


- -----------------------------

     (1)  Each of the milestone payments provided for in this Section 5.2 shall
be payable no more than once and shall encompass all Products taken together.

     (2)  Payable regardless of the territory in which such trial is conducted.
This milestone shall be satisfied in any event by a decision to proceed to a
Phase II clinical trial in influenza-infected patients.

     (3)  Payable for any such trial that would qualify as a Phase III Clinical
Trial for a U.S. NDA, even if such trial is conducted outside the U.S.

     (4)  [










                ]


                      [*] CONFIDENTIAL TREATMENT REQUESTED

                                       14.
<PAGE>

     5.3  ROYALTY PAYMENTS; ADJUSTMENTS.

               (a)  ROYALTY ON PRODUCTS.  Roche shall pay Gilead a royalty
payment on Net Sales of Product sold by Roche, its Affiliates or licensees (the
"Royalty") according to the following rates, as adjusted in accordance with
subsections (c), (d), (e) and (f) below:

                    (i)  [                   ] of worldwide Net Sales for the
first [          ] in Net Sales in a given calendar year;

                    (ii) [                   ] of worldwide Net Sales for the
[              ] in Net Sales during the same calendar year; and

                    (iii)  [                           ] of worldwide Net Sales
for Net Sales in excess of [               ] during the same calendar year.

     By way of example, if, in the year 2005, Roche's total Net Sales equal 
[             ] then the Royalty payable to Gilead hereunder shall equal 
[              ] calculated in the following manner:

     AMOUNT OF NET SALES          ROYALTY RATE           ROYALTY PAYMENT

     First [                                                             ]

     Next [                                                              ]

     Next [                                                              ]
                                                         ---------------
          Total Royalty                                  [               ]


               (b)  ROYALTY PAYMENT SCHEDULE.  For the first calendar year of
Net Sales, the Royalty shall be paid to Gilead in accordance with the schedule
set forth in subsection (a) above.  Beginning in the second calendar year of Net
Sales, Roche's first three (3) quarterly payments shall be based upon the
average royalty rate payable with respect to the previous calendar year.
Following the fourth (4th) quarter of each calendar year, Roche shall pay Gilead
the Royalty owing for the full year minus the aggregate payments made for the
first three quarters or, if the aggregate payments made for the first three
quarters exceed the Royalty owing for the full year, Gilead shall refund the
difference to Roche.

               (c)  UNLICENSED COMPETITION ADJUSTMENT.  Except as provided
below, if a Third Party not under license from Roche sells a Generically
Equivalent Product in a country or countries in which Roche, an Affiliate or
sublicensee is selling


                      [*] CONFIDENTIAL TREATMENT REQUESTED

                                       15.
<PAGE>

Product and the monetary value of such Third Party's sales of Generically 
Equivalent Product, as determined by a reliable Third Party and measured in a 
manner as near as practicable to the sales of Product in the same country, 
are equal to or greater than [                   ] of the monetary value of 
the Adjusted Gross Sales of Product in such country or countries, then the 
royalty payable by Roche to Gilead on Net Sales of Product in such 
country(ies) shall be reduced by [                  ] of the Royalty set 
forth in subsection (a), until such time as the Third Party's sales drop 
below [                      ] of the Adjusted Gross Sales in such 
country(ies).  The royalty reduction provided for in this paragraph (c) shall 
be inapplicable during any period of time that Gilead is diligently pursuing 
litigation to enforce Gilead Patent Rights or Joint Patent Rights to stop the 
sale of the Generically Equivalent Product in question in such country.

               (d)  COST OF GOODS SOLD ADJUSTMENT.  Except as provided below, 
if the Cost of Goods Sold for a Product exceeds [                   ] of the 
Net Sales of such Product in any particular calendar quarter, each measured 
on a worldwide basis, then the Royalty payable for such quarter shall be 
reduced by [         ] of the amount by which such Cost of Goods Sold exceeds 
[               ] of Net Sales.  Any Royalty reductions effected under this 
paragraph (d) shall be known as a "COGS Adjustment Amount", and shall become 
payable to Gilead in the future in any time period(s) in which the Cost of 
Goods Sold for the Product in question is less than [              ] of the 
Net Sales of such Product, each measured on a worldwide basis.  In such time 
periods, Gilead shall recover [         ] of the amount by which the Cost of 
Goods Sold is less than [               ] of Net Sales, until it has fully 
recovered the COGS Adjustment Amount, without interest.  This paragraph (d) 
shall not effect any reduction in the Royalty rate to less than [ 
      ] of the rate set forth in paragraph (a), and shall be inapplicable with 
respect to Product sales as to which adjustment is separately provided for 
under paragraph (c) or (e).

               (e)  SECONDARY PATENT COVERAGE.  The Royalty rates set forth in
paragraph (a) above are based on the assumption that one or more Valid Claims of
the Gilead Patent Rights, Roche Patent Rights or Joint Patent Rights, if any,
applicable to the Product in question will Cover the composition of matter of
the neuraminidase inhibitor which is an active ingredient in the Product.  If,
however, one or more Gilead Patent Rights, Roche Patent Rights or Joint Patent
Rights Cover the manufacture, use or sale of such Product, but there is no Valid
Claim Covering the composition of matter of the influenza neuraminidase
inhibitor which is an active ingredient in the Product, then the following
Royalty rates shall apply.  In the event a sale of a particular Product in a
particular country might be described in more than one of the following
subparagraphs, the highest royalty rate shall apply to such sale.

                    (i)  In any event, regardless of patent Coverage, each
Product shall be royalty-bearing at the rate set forth in paragraph (a), subject
to


                      [*] CONFIDENTIAL TREATMENT REQUESTED

                                       16.
<PAGE>

adjustment as provided elsewhere under this Agreement but not under this 
paragraph (e), for the first [          ] following First Commercial Sale 
in each country.  If following such [         ] period there is no patent 
Coverage for the manufacture, use or sale of the Product in a particular 
country, sales of such Product shall thereafter be royalty-free in that 
country.  If, however, after such [       ] period there is patent Coverage 
for the manufacture, use or sale of the Product, but not the composition of 
matter of the influenza neuraminidase inhibitor which is an active ingredient 
of the Product, then the royalties set forth in Sections 5.3(e)(ii)-(v) shall 
apply.

                    (ii) If the manufacture, use or sale of the Product (but not
the composition of matter of the influenza neuraminidase inhibitor which is an
active ingredient of the Product) is Covered by a Gilead Patent Right, then the
royalty rates set forth in paragraph (a) shall be reduced by [         ]  Such
reduced rate shall remain subject to further reduction pursuant to paragraph
(c), in which case the royalty rate could be reduced to [   ] of the rate set
forth in paragraph (a), but there shall not be any reduction pursuant to
paragraph (d) or by reason of Third Party license fees as described in Section
10.4.

                    (iii)     If the manufacture, use, or sale of the Product 
(but not the composition of matter of the influenza neuraminidase inhibitor 
which is an active ingredient of the Product) is Covered By a Joint Patent 
Right, then the royalty rates set forth in paragraph (a) shall be reduced to 
[   ] of such rate.  Such reduced rate shall remain subject to further 
reduction pursuant to paragraph (c) but only to a royalty rate which is [   ] 
of the rate set forth in paragraph (a), and there shall not be any reduction 
pursuant to paragraph (d) or by reason of Third Party license fees as 
described in Section 10.4.

                    (iv) If the manufacture, use or sale of the Product (but 
not the composition of matter of the influenza neuraminidase inhibitor which 
is an active ingredient of the Product) is Covered by a Roche Patent Right 
based on an invention made or obtained in connection with Roche's work 
related to Products, then the royalty rate set forth in paragraph (a) shall 
be reduced to [    ] of such rate.  Such reduced rate shall not be subject to 
any further reduction under this Agreement.

                    (v)  If the manufacture, use or sale of the Product (but not
the composition of matter of the influenza neuraminidase inhibitor which is an
active ingredient of the Product) is Covered only by a Valid Claim of a Roche
patent based on an invention by Roche, which invention was made independently of
Roche's work related to Products resulting from the Development Plan, then no
royalty shall be due under this Agreement.

               (f)  SUMMARY OF RULES REGARDING ROYALTY ADJUSTMENTS.  In
implementing the various Royalty adjustment provisions of this Agreement:


                      [*] CONFIDENTIAL TREATMENT REQUESTED

                                       17.
<PAGE>

                    (i)  Royalty reductions under paragraphs (c) and (e) 
shall be determined on a country by country basis.  If a Royalty adjustment 
is called for in one or more countries, but not worldwide, then the Royalty 
shall be calculated initially as set forth in paragraph (a), and the Royalty 
reduction shall be applied on the basis of the average worldwide Royalty rate 
otherwise payable.

                    (ii) If an adjustment is made under paragraph (c)
(Unlicensed Competition Adjustment), then there shall not be any adjustment
under paragraph (d) (Cost of Goods Sold Adjustment) with respect to the same
sale of Product.

                    (iii)     If an adjustment is made under paragraph (e)
(Secondary Patent Coverage), then such reduced rate shall still be subject to
further reduction as provided in paragraph (c) (Unlicensed Competition
Adjustment), in which case the Royalty could be reduced to [  ] of the rate set
forth in paragraph (a), but there shall not be any reduction under paragraph (d)
(Cost of Goods Sold Adjustment) or by reason of Third Party license fees as
described in Section 10.4.

                    (iv) Except as expressly provided in Sections 5.3(e)(ii)-
(v), the Royalty rate shall not be reduced to less than [                ] of
the rate set forth in Section 5.3(a).

               (g)  EXPIRATION OF ROYALTY OBLIGATIONS.  The royalty obligations
set forth in subsection (a) above shall expire on a country-by-country basis
upon the later of: (i) in those countries in which a Gilead Patent Right, Joint
Patent Right or Roche Patent Right covers the manufacture, use or sale of a
Product sold by Roche, its Affiliate or a licensee, the date upon which the
manufacture, use or sale of such Product would no longer infringe a Valid Claim
of a Gilead Patent Right, Joint Patent Right or Roche Patent Right in the
absence of rights thereunder; and (ii) [           ] after the date of First
Commercial Sale of the Licensed Product in such country(ies).

     5.4  SUBLICENSE.  In the event Roche sublicenses its right to sell a
Product, such sublicenses shall include an obligation for the sublicensee to
account for and report its Net Sales of such Product on the same basis as if
such sales were Net Sales of Product by Roche, and Roche shall pay the
applicable Royalty to Gilead as if the Net Sales of the sublicensee were Net
Sales of Roche.

     5.5  PAYMENT STRUCTURE.  The effect of this Article 5 is to provide for a
royalty payment to Gilead for any Product discovered, developed or acquired by
either party prior to the fifth anniversary of the Effective Date of this
Agreement, whether or not such Product is Covered by a patent and irrespective
of which party owns or controls any relevant patents.  In establishing this
payment structure, the parties seek to create incentives for a highly effective
collaboration relating to Products with minimum potential for disputes,
including by way of example possible disagreements related to the


                      [*] CONFIDENTIAL TREATMENT REQUESTED

                                       18.
<PAGE>

allocation of work and the determination of inventorship; to recognize that
discoveries and developments related to influenza neuraminidase inhibitors after
the Effective Date are likely to constitute improvements on existing Gilead
Know-How, whether or not such new developments are within the scope of Gilead
Patents; and to provide incentive compensation to Gilead for its anticipated
work during the term of this Agreement, in addition to the grant of a patent
license, to enable the rapid and effective market introduction of Products
worldwide.  Roche acknowledges that Gilead has offered, and Roche has
voluntarily declined, a royalty arrangement under which Roche would pay
independent royalties on Gilead Know-How and Gilead Patent Rights, and that
instead of such independent royalties Roche has negotiated the royalty
adjustment provisions of this Section 5.3.

                                    ARTICLE 6

                                  MANUFACTURING

     6.1  PRE-COMMERCIAL MANUFACTURING.  It is the intention of the parties that
initial pre-clinical and clinical Products, including the bulk drug substance
contained therein, will be produced by Gilead, and that so long as it shall do
so the cost of such manufacturing will be included in Development Costs.  The
parties also understand that as part of the Development Plan and the Budget they
will cooperate to improve the manufacturing process in existence as of the
Effective Date.  Roche may assume full control of clinical manufacturing of
Products at its own expense at any time it desires upon written notice to
Gilead, and shall in any event have the sole and exclusive responsibility for
the manufacture of clinical Products not later than the commencement of Phase
III Clinical Trials for the initial Product.

     6.2  COMMERCIAL MANUFACTURING.   Roche shall be solely and exclusively
responsible at its own expense for commercial manufacture of Products, either
itself or through Third Parties.


                                       19.
<PAGE>

                                    ARTICLE 7

                                    MARKETING

     7.1  PRICING.  Roche shall determine, in its sole discretion, the pricing,
discounting policy and other commercial terms relating to Products.

     7.2  USE OF THE GILEAD NAME.  Gilead and Roche agree that the packaging and
promotional materials for the Product marketed by Roche and/or Roche's
sublicensees shall identify Gilead as licensor.  Roche hereby acknowledges
Gilead's ownership of the Gilead Sciences name.  Gilead hereby agrees to
indemnify and hold Roche harmless from any use hereunder of the Gilead Sciences
name which occurs with the consent of Gilead, provided that Roche provides
Gilead prompt notice of any such claim and grants to Gilead the exclusive
ability to defend (with the reasonable cooperation of Roche) and settle any such
claim.  If only one name is allowed to be in any specific item of packaging or
promotional material pursuant to governmental laws or regulations, then Roche
may use its name alone on such item, without identifying Gilead as licensor.

                                    ARTICLE 8

                            PAYMENTS; RECORDS; AUDIT

     8.1  PAYMENT; REPORT.  All amounts payable to either party under this
Agreement shall be paid in U.S. dollars within [            ] of the end of
each calendar quarter or as otherwise specifically provided herein.  Each
payment of royalties owing to Gilead shall be accompanied by a statement, on a
country-by-country basis, of the amount of gross sales, an itemized calculation
of Adjusted Gross Sales and Net Sales showing deductions provided for in Section
1.15 during such quarter, the amount of aggregate worldwide gross sales,
Adjusted Gross Sales and Net Sales during such quarter and on a cumulative basis
for the current year and the amount of Royalty or other payments due on such
sales.  If any Royalty reductions are claimed by Roche under this Agreement from
the full rates set forth in Section 5.3(a), then the report shall set forth in
detail the claimed reduction and the related facts.

     8.2  EXCHANGE RATE; MANNER AND PLACE OF PAYMENT.  All payments due
hereunder from time to time shall be paid in U.S. Dollars.  For purposes of
computing such payments, the Net Sales of Product in countries other than the
United States shall be converted into U.S. Dollars as computed in the central
Roche currency conversion system, using the average monthly rate of exchange at
the time for such currencies as retrieved from the Reuters System used by Roche.
If convenient for Roche, such conversion may be made initially into Swiss Francs
and then into U.S. Dollars for purposes of calculating the Royalty, provided
that Gilead is not disadvantaged by reason


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                                       20.
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of such multiple conversions (e.g., that the conversion rates used by Roche do
not reflect transaction costs of conversion).  The currency conversion system
used by Roche shall be subject to audit by Gilead as described in Section 8.3
and, if not determined to be a system reflecting the fair market value of the
currencies in question, shall be modified as necessary to effect currency
conversion at fair market value.

     Notwithstanding the foregoing, if by reason of any restrictive exchange
laws or regulations, Roche shall be unable to convert to U.S. Dollars the
amount, determined as above, equivalent to the amount due by Roche hereunder,
then Roche shall so notify Gilead promptly and provide an explanation of the
circumstances.  In such event, Roche shall make all such payments or the balance
thereof due hereunder and which is not paid in foreign currency as provided
below, in U.S. Dollars as soon as reasonably possible after and to the extent
that such restrictive exchange laws or regulations are lifted so as to permit
Roche to pay amounts due under this Section 8.2 in U.S. Dollars.  Roche shall
promptly notify Gilead if such restrictions are so lifted.  At its option Gilead
shall meanwhile have the right to request the payment (to it or to its nominee),
and, upon request, Roche shall pay or cause to be paid amounts due (or such
portions thereof as are specified by Gilead) in the currency of any other
country designated by Gilead and legally available to Roche under the then-
existing laws of regulations.  Any payments shall be payable to Gilead by wire
transfer at such bank in the United States as Gilead shall specify from time to
time.  Not less than one (1) business day prior to such wire transfer, the
remitting party shall telefax the receiving party advising it of the amount and
of the payment to be made.

     8.3  RECORDS AND AUDIT.  Roche shall keep, and shall cause its Affiliates
and sublicensees to keep, complete and accurate records pertaining to the sale
or other disposition of Product and of the Royalty and other amounts payable
under this Agreement in sufficient detail to permit Gilead to confirm the
accuracy of all payments due hereunder.  At Gilead's request, Roche will cause
its independent certified public accountants to prepare abstracts of Roche's
relevant business records for review by Gilead's independent certified public
accountants.  If, based on a review of such abstracts, Gilead reasonably
believes that a full audit of said business records would be necessary for the
confirmation of the accuracy of all payments due hereunder, Gilead's independent
certified public accountants shall have full access to review all work papers
and supporting documents pertinent to such abstracts, and shall have the right
to discuss such documentation with Roche's independent certified public
accountants. [








                      [*] CONFIDENTIAL TREATMENT REQUESTED


                                       21.
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                                                                            ]
Such audit rights may be exercised no more often than once a year, within three
(3) years after the payment period to which such records relate, upon notice to
Roche and during normal business hours.  Gilead will bear the full cost of such
audit unless such audit discloses an underpayment of more than five percent (5%)
from the amount of royalties due. Roche shall promptly make up any underpayment.
The terms of this Section 8.3 shall survive any termination or expiration of
this Agreement for a period of three (3) years.

     8.4  WITHHOLDING TAXES.  Any and all taxes levied on account of royalty
payments paid or owed from a country in which provision is made in the law or by
regulation for withholding will be deducted from royalty payments made to Gilead
hereunder.  Roche shall cooperate with Gilead to claim exemption from such
deductions or withholdings under any double taxation or similar agreement in
force from time to time.  In addition, Roche shall cooperate with Gilead in all
proper respects to minimize any taxes on royalties hereunder.  If Roche makes
any payment without reduction for withholding and it later transpires that an
amount of tax should have been withheld on such royalty payment ("underwithheld
tax"), Roche shall be entitled to recover the underwithheld tax by an additional
withholding from any payment due to Gilead under this Agreement.  Similarly, if
Roche withholds an amount of tax which is later determined to have not been due,
Roche shall reimburse Gilead for such over withheld amounts.  Gilead shall have
the right to audit correspondence and records relating to such tax issues on the
same terms as described in Section 8.3 above.

                                    ARTICLE 9

                              TERM AND TERMINATION

     9.1  TERM.  The term of this Agreement shall commence upon the Effective
Date and, unless sooner terminated as provided in this Article 9, expire on the
expiration of royalty obligations set forth herein.

     9.2  LICENSES UPON EXPIRATION.  In the event that the Agreement expires as
set forth in Section 9.1 above without early termination, the license granted
under Section 2.1 with respect to the Gilead Patents and Gilead Know-How shall
automatically become a non-exclusive, irrevocable, fully-paid license to use
and/or sublicense the use of Gilead Know-How to manufacture, use and sell
Products in each country where such license had previously been in effect.  In
the event one or more countries are eliminated from the 


                      [*] CONFIDENTIAL TREATMENT REQUESTED

                                       22.
<PAGE>

scope of the Roche license pursuant to Section 4.2 or 9.6, the license to 
Roche in this Section 9.2 shall not apply to such countries.

     9.3  TERMINATION FOR BREACH.  Each party shall have the right to terminate
this Agreement and its obligations hereunder for material breach by the other
party, which breach remains uncured for ninety (90) days after written notice is
provided to the breaching party, or in the case of an obligation to pay a
Royalty or other payments owing under this Agreement, which breach remains
uncured for thirty (30) days after written notice to the breaching party unless
there exists a bona fide dispute as to whether such Royalty or other payments
are owing. Notwithstanding any termination under this Section 9.3, any
obligation to pay Royalty or other payments which had accrued or become payable
as of the date of termination shall survive termination of this Agreement.

     9.4  TERMINATION FOR GILEAD'S BREACH.  In the event Roche terminates this
Agreement pursuant to Section 9.3 above, all licenses granted to Roche under
this Agreement shall survive, subject to Roche's continued obligation to pay
Royalties to Gilead hereunder.  Roche shall retain all of its rights to bring an
action against Gilead under Article 14, including all of its rights for recovery
of damages.

     9.5  PRODUCT REVERSION.  In the event Gilead terminates this Agreement 
pursuant to Section 9.3 above, or Roche terminates this Agreement pursuant to 
Section 9.6, all licenses granted to Roche under Section 2.1 hereof shall 
terminate, all rights to Products shall automatically revert to Gilead, and 
Roche shall cooperate with Gilead in all respects to effect the prompt and 
efficient transfer to Gilead of Product development and marketing activities. 
In the event of such termination, Roche hereby assigns to Gilead all right, 
title and interest in and to all regulatory filings and approvals pertaining 
to Products.  In addition, contingent upon such termination, Roche hereby 
grants to Gilead an exclusive, royalty-free license under the Roche Patents 
and the Roche Know-How which are necessary or useful for the manufacture, use 
or sale of the Product(s) as such product(s) exist as of the date of 
termination.  Gilead's rights to practice such Roche technology shall be 
limited exclusively to the purpose of development and commercialization of 
products that would be Products hereunder.  If Roche terminates its rights in 
one or more countries under Section 9.6, or loses its rights in one or more 
countries pursuant to Section 4.2, this Section 9.5 shall apply only in the 
countries in which such termination is effective.  If such termination occurs 
on less than a worldwide basis, Roche shall (i) supply the requirements of 
Gilead or its subsequent licensee for Product (in bulk or finished form), or 
intermediates of such Product, at Roche's Cost of Goods Sold, so long as 
Roche manufactures or procures the Product or intermediate for its own 
account, and (ii) at Gilead's request, assist reasonably in the transfer of 
manufacturing processes to new suppliers.  If such termination occurs on a 
worldwide basis, then Roche shall (i) provide such supply, to the extent it 
had established it for its own account prior to such termination, and (ii) at 
Gilead's request, assist reasonably in 


                                       23.
<PAGE>

the transfer of manufacturing processes to new suppliers.  Gilead agrees that 
in the event this Section 9.5 comes into effect, it will use diligent efforts 
to effect the transfer of Product manufacturing activities to Third Parties 
as soon as practicable. Roche's supply obligation under this Section 9.5 
shall in any event not continue for more than two (2) years after such 
termination.

     9.6  TERMINATION BY ROCHE FOR CONVENIENCE.  Roche shall also have the 
right in its discretion to terminate this Agreement on a worldwide basis or 
on a country by country basis, on [                   ] advance written 
notice, provided that (i) Roche shall remain responsible for its performance 
of this Agreement during the [        ] period following the giving of such 
notice, (ii) Roche shall remain responsible for the completion of any 
clinical trials of Product which commenced prior to the giving of such 
notice, even if such trial continued beyond such [                 ] period, 
and (iii) on a worldwide or country by country basis, as the case may be, 
Roche shall grant the licenses and effect the transfers provided for in 
Section 9.5.  In such event, if Gilead grants a license to a Third Party to 
the Product rights surrendered by Roche prior to the end of such 
[              ] period, Gilead shall use diligent efforts to cause such 
new licensee to assume its PRO RATA share of the costs for which Roche is 
responsible under this Section 9.6 in respect of the Product rights being 
obtained by the new licensee (where "PRO RATA" refers to the period of time 
remaining in the [              ] notice period at the time Gilead enters 
into such new agreement).

     9.7  SURVIVAL.  Articles 1, 5, 9, 10, 11, 12, 14 and 15 and Sections 3.3(b)
and 8.3 of this Agreement shall survive termination of this Agreement for any
reason (subject to any subsequent dates of termination referred to in such
individual Articles).

                                   ARTICLE 10

                              INTELLECTUAL PROPERTY

     10.1 OWNERSHIP OF INVENTIONS.  Each party shall own any inventions made
solely by its employees or agents.  Inventions made jointly by employees or
agents of each party shall be owned jointly by the parties ("Joint Inventions").
Inventorship shall be determined in accordance with U.S. patent laws.

     10.2 PROSECUTION OF PATENTS.

               (a)  GILEAD PATENTS.  Gilead Patents shall be prosecuted
(including the handling of interferences) and maintained by Gilead or its
licensors.  Gilead shall furnish Roche with copies of draft submissions to the
relevant patent authorities and will consider Roche's comments.  If Roche does
not provide Gilead with comments within thirty (30) days of receipt of a draft,
Gilead shall be free to proceed with its submission or other contemplated
action.  Further, Gilead shall always be entitled


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<PAGE>

to proceed with any submission or other contemplated action if it determines 
time is of the essence, provided that Gilead makes reasonable efforts to 
inform Roche as early as practicable and to consider its comments where 
possible.  In the event that Gilead elects not to maintain any issued patent 
within the Gilead Patents or not to file any patent term extensions to the 
Gilead Patents which Roche believes are appropriate to obtain an extended 
period of market exclusivity for Product, Roche shall have the right to elect 
to have Gilead or its licensors maintain such patents or file for such patent 
term extensions at Roche's sole expense.  Gilead shall bear the costs 
incurred in connection with the prosecution and maintenance of Gilead 
Patents, except that Roche shall make a one-time nonaccountable and 
noncreditable payment to Gilead in the amount of [         ] within ten (10) 
days of the Effective Date as an additional license fee in consideration of 
Gilead's obligation to prosecute and maintain the Gilead Patents after the 
Effective Date.

               (b)  ROCHE PATENTS COVERING PRODUCTS.  It is anticipated that as
part of this collaborative development program, patents may be filed by and
issued to Roche that may cover compositions of matter (including formulations)
of Products as well as biological uses or processes for the manufacture of
Products.  These patents shall be prosecuted (including the handling of
interferences) and maintained by Roche, at its expense.  Roche shall furnish
Gilead with copies of draft submissions to the relevant patent authorities and
will consider Gilead's comments.   If Gilead does not provide Roche with
comments within thirty (30) days of receipt of a draft, Roche shall be free to
proceed with its submission or other contemplated action.  Further, Roche shall
always be entitled to proceed with any submission or other contemplated action
if it determines time is of the essence, provided that Roche makes reasonable
efforts to inform Gilead as early as practicable and to consider its comments
where possible.  Roche shall not abandon claims Covering Products without prior
notice to and consultation with Gilead, and shall not abandon patent
applications covering Products without first offering assignment of such
applications to Gilead, which if it accepts such assignment shall thereafter
prosecute such applications at its sole expense and in its sole discretion.  In
the event such applications are assigned to Gilead, Roche shall retain a
nonexclusive license.  Such license shall be royalty free outside of the field
of neuraminidase inhibitors, and shall be subject to the Royalties set forth in
Section 5.3 within the field of neuraminidase inhibitors.

               (c)  JOINT PATENTS.  With respect to Joint Inventions, the
parties shall meet and agree upon which party shall prosecute patent
applications Covering such Joint Invention.  If either party prosecutes a patent
application on a Joint Invention, such party shall bear its own internal costs,
and the external costs for outside counsel, filing fees, etc. shall be borne
equally by the parties, except as provided in the final sentence of this
paragraph.  Except for the licenses granted herein, each party shall be entitled
to practice and sublicense Joint Inventions without restriction or an obligation
to account to the other party.  Either party may disclaim its interest in any
particular patent or patent


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                                       25.
<PAGE>

application covering a Joint Invention, in which case (i) the disclaiming party
shall assign its ownership interest in such patent or patent application to the
other party without consideration, (ii) the party which is then the sole owner
shall be solely responsible for all future costs of such patent or patent
application, and (iii) the disclaiming party shall hold no further rights
thereunder, except for a nonexclusive license. Such license shall be royalty
free outside of the field of neuraminidase inhibitors, and shall be subject to
the Royalties set forth in Section 5.3 within the field of neuraminidase
inhibitors.

     10.3 INFRINGEMENT OF PATENTS BY THIRD PARTIES.

               (a)  NOTIFICATION.  Each party shall promptly notify the other in
writing of any alleged or threatened infringement of the Gilead Patent Rights,
Joint Patent Rights or Roche Patent Rights of which it becomes aware.

               (b)  GILEAD PATENT RIGHTS.  Gilead shall have the right, but not
the obligation, to bring, at Gilead's expense and in its sole control, an
appropriate action against any person or entity infringing a Gilead Patent Right
directly or contributorily.  If Gilead does not bring such action within ninety
(90) days (forty five (45) days in the case of an action brought under the
Hatch-Waxman Act) of notification thereof to or by Roche, Roche shall have the
right, but not the obligation, to bring at Roche's expense and in its sole
control, such appropriate action.  The party not bringing an action under this
paragraph (b) shall be entitled to separate representation in such matter by
counsel of its own choice and at its own expense, but such party shall cooperate
fully with the party bringing such action.

               (c)  ROCHE PATENT RIGHTS.  With respect to Roche Patent Rights,
Roche may take such action as it deems in its best interests.  Gilead shall not
have any right to bring an action under Roche Patent Rights, but shall have the
right to be fully informed regarding any litigation brought thereunder by Roche,
including the status of any settlement activity.

               (d)  JOINT PATENT RIGHTS.  With respect to Third Party
infringement of Joint Patent Rights, the parties shall confer and take such
action, and allocate expenses and recoveries in such manner, as they may agree.
In the absence of agreement, the rules applicable to Gilead Patent Rights shall
apply to the Joint Patent Rights in question.

               (e)  COSTS AND AWARDS.  The party which is not in control of any
action brought pursuant to Section 10.3(b), (c) or (d) may elect to contribute
fifty percent (50%) of the costs of litigation against such Third Party
infringer, by providing written notice to the controlling party within ninety
(90) days after such action is first brought.  If


                                       26.
<PAGE>

the non-controlling party elects to bear fifty percent (50%) of such litigation
costs, it shall receive fifty percent (50%) of any damage award or settlement
resulting from such action.  If the non-controlling party does not elect to
share such litigation costs, it shall not participate in any damage award or
settlement resulting from such action.

               (f)  SETTLEMENT;  ALLOCATION OF PROCEEDS.  Neither party shall
settle a claim brought under this Section 10.3 without the consent of the other
party.  In the event of any recovery of monetary damages from the Third Party,
whether such damages result from the infringement of Gilead Patents or Roche
Patents, such recovery shall be allocated first to the reimbursement of any
expenses incurred by the parties in the litigation under this Section 10.3
(including, for the purpose, a reasonable allocation of internal counsel and
other expenses), and thereafter as provided in Section 10.3 (e).  If the amount
recovered from the Third Party is less than the aggregate expenses of the
parties incurred in connection with such litigation, the recovery shall be
shared pro rata between Gilead and Roche in proportion to their respective
expenses.

     10.4 INFRINGEMENT OF THIRD PARTY RIGHTS.  In the event that any Product 
manufactured, used or sold under this Agreement becomes the subject of a 
Third Party claim or there is the potential for a claim for patent 
infringement anywhere in the world, and irrespective of whether Gilead or 
Roche is charged with said infringement, the parties shall promptly meet to 
consider the claim and the appropriate course of action.  Unless the parties 
otherwise agree, the party against which such Third Party infringement claim 
is brought shall defend against such claim at its sole expense and the other 
party shall have the right, but not the obligation, to participate in any 
such suit, at its sole option and at its own expense.  Such other party shall 
reasonably cooperate with the party conducting the defense of the claim, 
including if required to conduct such defense, furnishing a power of 
attorney.  Neither party shall enter into any settlement that affects the 
other party's rights or interests without such other party's written consent, 
which consent shall not be unreasonably withheld.  If in the opinion of 
Roche's counsel, a license with respect to such Third Party patents is 
necessary to avoid substantial risks which could prevent Roche from making, 
using, selling, offering for sale or importing Product, then Roche shall 
notify Gilead of such conclusion and the basis for it and give Gilead a 
reasonable opportunity to discuss Roche's opinion.  If Gilead concurs in 
Roche's opinion, Roche shall have the right to negotiate directly with such 
Third Party for a license, and Roche shall be entitled to apply 
[                   ] of Third Party Royalties for Net Sales in the country 
where the claim exists, as a credit against royalties due under Section 5.3; 
provided, however, that the aggregate credit taken in any given calendar 
quarter shall not exceed [                ] of the royalties payable to 
Gilead during that quarter, on a country-by-country basis, and shall be 
subject to further limitations as expressly set forth in Section 5.3.  If 
Gilead does not concur with Roche's opinion, the matter shall be submitted to 
an independent counsel, selected by mutual consent and paid equally by Roche 
and Gilead, to determine whether there is a substantial


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                                       27.
<PAGE>

risk of infringement of such Third Party rights.  If such independent counsel
determines that a substantial risk exists, then Roche may negotiate directly
with such Third Party and receive royalty credit as set forth above.  If such
independent counsel determines that a substantial risk does not exist, then
Roche may still negotiate for a license from such Third Party if it elects to do
so, but Roche shall not have the right of royalty reduction provided for in this
Section 10.4.

     10.5 PATENT MARKING.  Products marketed and sold by Roche hereunder shall
be marked with appropriate patent numbers or indicia at Gilead's request,
subject to Roche's consent, not to be unreasonably withheld.

                                   ARTICLE 11

                                 INDEMNIFICATION

     11.1 INDEMNIFICATION BY GILEAD.  Gilead hereby agrees to indemnify, hold
harmless and defend Roche against any and all expenses, costs of defense
(including without limitation attorneys' fees, witness fees, damages, judgments,
fines and amounts paid in settlement) and any amounts Roche becomes legally
obligated to pay because of any claim or claims against it to the extent that
such claim or claims (i) arise out of the breach or alleged breach of any
representation or warranty by Gilead hereunder, or (ii) are due to the
negligence or misconduct of Gilead; provided that (a) Roche provides Gilead with
prompt notice of any such claim and the exclusive ability to defend (with the
reasonable cooperation of Roche) and settle any such claim and (b) such
indemnities shall not apply to the extent such claims are covered by Roche's
indemnity set forth in Section 11.2 below.

     11.2 INDEMNIFICATION BY ROCHE.  Roche hereby agrees to indemnify, hold
harmless and defend Gilead against any and all expenses, costs of defense
(including without limitation attorneys' fees, witness fees, damages, judgments,
fines and amounts paid in settlement) and any amounts Gilead becomes legally
obligated to pay because of any claim or claims against it to the extent that
such claim or claims (i) result from Roche's activities under this Agreement,
(ii) arise out of the breach or alleged breach of any representation or warranty
by Roche hereunder, (iii) are due to the negligence or misconduct of Roche, or
(iv) arise out of the possession, manufacture, use, sale or administration of
the Product by Roche or Roche's Affiliates or sublicensees; provided that (a)
Gilead provides Roche with prompt notice of any such claim and the exclusive
ability to defend (with the reasonable cooperation of Gilead) or settle any such
claim and (b) such indemnities shall not apply to the extent such claims are
covered by Gilead's indemnity set forth in Section 11.1 above.

     11.3 MECHANICS.  In the event that the parties cannot agree as to the
application of Sections 11.1 and 11.2 above to any particular loss or claim, the
parties may conduct


                                       28.
<PAGE>

separate defenses of such claim.  Each party further reserves the right to claim
indemnity from the other in accordance with Sections 11.1 and 11.2 above upon
resolution of the underlying claim, notwithstanding the provisions of Sections
11.1 and 11.2 above requiring the indemnified party to tender to the
indemnifying party the exclusive ability to defend such claim or suit.

     11.4 INSURANCE COVERAGE.  Each party represents and warrants that it is
covered and will continue to be covered by a comprehensive general liability
insurance program which covers all of each Party's activities and obligations
hereunder. Each party shall provide the other party with written notice at least
fifteen (15) days prior to any cancellation or material change in such insurance
program.  Each party shall maintain such insurance program, or other program
with comparable coverage, beyond the expiration or termination of this Agreement
during (i) the period that any Product is being commercially distributed or sold
other than for the purpose of obtaining regulatory approvals by Roche or by a
sublicensee, Affiliate or agent of Roche and (ii) a commercially reasonable
period thereafter.


                                       29.
<PAGE>

                                   ARTICLE 12

                                 CONFIDENTIALITY

     12.1 PROPRIETARY INFORMATION; EXCEPTIONS.  Each party will maintain all
Proprietary Information received by it under this Agreement in trust and
confidence and will not disclose any such Proprietary Information to any Third
Party or use any such Proprietary Information for any purposes other than those
necessary or permitted for performance under this Agreement.  In particular,
Roche shall not use any Gilead Know-How for any purpose other than those
expressly licensed under Section 2.1.  Each party may use the other's
Proprietary Information only to the extent required to accomplish the purposes
of this Agreement.  Proprietary Information shall not be used for any purpose or
in any manner that would constitute a violation of any laws or regulations,
including without limitation the export control laws of the United States.
Proprietary Information shall not be reproduced in any form except as required
to accomplish the intent of this Agreement.  No Proprietary Information shall be
disclosed to any employee, agent, consultant, Affiliate, or sublicensee who does
not have a need for such information.  To the extent that disclosure is
authorized by this Agreement, the disclosing party will obtain prior agreement
from its employees, agents, consultants, Affiliates, sublicensees or clinical
investigators to whom disclosure is to be made to hold in confidence and not
make use of such information for any purpose other than those permitted by this
Agreement.  Each party will use at least the same standard of care as it uses to
protect its own Proprietary Information of a similar nature to ensure that such
employees, agents, consultants and clinical investigators do not disclose or
make any unauthorized use of such Proprietary Information, but no less than
reasonable care.  Each party will promptly notify the other upon discovery of
any unauthorized use or disclosure of the Proprietary Information.

     Proprietary Information shall not include any information which:

               (a)  is now, or hereafter becomes, through no act or failure to
act on the part of the receiving party in breach hereof, generally known or
available;

               (b)  is known by the receiving party at the time of receiving
such information, as evidenced by its written records;

               (c)  is hereafter furnished to the receiving party by a third
party, as a matter of right and without restriction on disclosure;

               (d)  is independently developed by the receiving party without
any breach of this Agreement; or


                                       30.
<PAGE>

               (e)  is the subject of a written permission to disclose provided
by the disclosing party.

     12.2 AUTHORIZED DISCLOSURE.  The parties shall issue a joint press release
upon signing this Agreement.  The parties agree that the material financial
terms of the Agreement, other than the initial payments provided in Sections
3.3(c) and 5.1 and the aggregate milestone payments provided for in Section 5.2,
will be considered Proprietary Information of both parties.  Notwithstanding the
foregoing, either party may make disclosures required by law or regulation,
provided prior notice is given to the other party whenever possible, and may
disclose the material financial terms of the Agreement to bona fide potential
corporate partners, to the extent required or contemplated by this Agreement,
and to financial underwriters, prospective investors and other parties with a
need to know such information.  Any such disclosures, and any disclosure of the
development and marketing or Products or other developments under this
Agreement, including but not limited to press releases, will be reviewed and
consented to by each party prior to such disclosure.  Such consent shall not be
untimely or unreasonably withheld by either party.  All such disclosures shall
be made only to parties under an obligation of confidentiality.

     Notwithstanding any other provision of this Agreement, each party may
disclose Proprietary Information if such disclosure:


               (a)  is in response to a valid order of a court or other
governmental body of the United States or a foreign country, or any political
subdivision thereof; provided, however, that the responding party shall first
have given notice to the other party hereto and shall have made a reasonable
effort to obtain a protective order requiring that the Proprietary Information
so disclosed be used only for the purposes for which the order was issued;

               (b)  is otherwise required by law or regulation, including SEC
related documents; or


               (c)  is otherwise necessary to file or prosecute patent
applications, prosecute or defend litigation or comply with applicable
governmental regulations or otherwise establish rights or enforce obligations
under this Agreement, but only to the extent that any such disclosure is
necessary.

     12.3 RETURN OF PROPRIETARY INFORMATION.  In the event Roche loses its
license to Gilead Patents and Gilead Know-How which was granted to it under this
Agreement, Roche shall use diligent efforts (including without limitation a
diligent search of files and computer storage devices) to return all Proprietary
Information received by it from Gilead, provided, however, that Roche may keep
one copy of such Proprietary Information for legal archival purposes.  Access to
the copy so retained by Roche's legal


                                       31.
<PAGE>

department shall be restricted to counsel and such Proprietary Information shall
not be used except in the resolution of any claims or disputes arising out of
this Agreement.

     12.4 PUBLICATIONS.  Except as required by law, neither Party shall publish
or present, or cause to be published or presented, the results of studies
carried out with respect to Products without the opportunity for prior review by
the other party.  Each party shall provide to the other the opportunity to
review any proposed abstracts, manuscripts or presentations which relate to
Products at least thirty (30) days prior to their intended submission for
publication and such submitting party agrees, upon written request from the
other party, not to submit such abstract or manuscript for publication or to
make such presentation until the other party is given a reasonable period of
time to seek patent protection for any material in such publication or
presentation that it believes is patentable.

                                   ARTICLE 13

                         REPRESENTATIONS AND WARRANTIES

     13.1 MUTUAL REPRESENTATIONS AND WARRANTIES.  Each party hereby represents
and warrants:

               (a)  CORPORATE POWER.  Such party is duly organized and validly
existing under the laws of the state of its incorporation and has full corporate
power and authority to enter into this Agreement and to carry out the provisions
hereof.

               (b)  DUE AUTHORIZATION.  Such party is duly authorized to execute
and deliver this Agreement and to perform its obligations hereunder.

               (c)  BINDING AGREEMENT.  This Agreement is a legal and valid
obligation binding upon it and is enforceable in accordance with its terms.  The
execution, delivery and performance of this Agreement by such party does not
conflict with any agreement, instrument or understanding, oral or written, to
which it is a party or by which it may be bound, nor violate  any law or
regulation of any court, governmental body or administrative or other agency
having authority over it.

     13.2 GILEAD REPRESENTATIONS AND WARRANTIES.  Gilead warrants and represents
that:

          (a)  SAFETY DATA.  To the best of its knowledge, Gilead has informed
Roche about all significant information in its possession or control concerning
side effects, injury, toxicity or sensitivity reaction and incidents or severity
thereof with respect to any Product tests conducted by Gilead or its
contractors.  Roche acknowledges


                                       32.
<PAGE>

that such tests have been entirely preclinical and may not be indicative of
results that may be obtained in humans.

          (b)  PATENT MATTERS.  As of the Effective Date, Gilead has no
knowledge of the existence of any patent owned or controlled by a Third Party
which covers the lead compound identified by Gilead to Roche (GS 4104) and would
prevent Roche from making, using or selling such compound.  To the best of
Gilead's knowledge and belief, as of the Effective Date, the patent applications
listed in Exhibit A at the Effective Date are owned by Gilead and Gilead is not
in possession of information that would, in its opinion, render invalid and/or
unenforceable claims directed specifically to GS 4104 that are presently in one
or more of such applications.  Notwithstanding the foregoing, if at any time
prior to December 31, 1997, a patent or patent application held by a Third Party
is identified which covers the specific Product being developed by the parties
pursuant to this Agreement, the parties will meet and discuss possible
resolutions of the patent situation.  If the resolution involves a license from
the Third Party to its patent rights and/or a license to the Third Party under
Gilead or Roche patent rights, the parties acknowledge that the economic
assumptions underlying this Agreement may no longer be valid, and in such case
the parties will renegotiate the terms of this Agreement in good faith in order
to reflect such resolution.

     13.3 NO OTHER REPRESENTATIONS. THE EXPRESS REPRESENTATIONS AND WARRANTIES
STATED IN THIS ARTICLE 13 ARE IN LIEU OF ALL OTHER REPRESENTATIONS AND
WARRANTIES, EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION, THE WARRANTIES OF
MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE.

                                   ARTICLE 14

                  DISPUTE RESOLUTIONS; VENUE AND GOVERNING LAW

     14.1 DISPUTES.  The parties recognize that disputes as to certain matters
may from time to time arise during the term of this Agreement which relate to
either party's rights and/or obligations hereunder or thereunder.  It is the
objective of the parties to establish procedures to facilitate the resolution of
disputes arising under this Agreement in an expedient manner by mutual
cooperation and without resort to litigation.  To accomplish this objective, the
parties agree to follow the procedures set forth in this Article 14 if and when
a dispute arises under this Agreement.

     In the event of disputes between the parties, including disputes among the
members of the Steering Committee which such committee is unable to resolve, a
party seeking to resolve such dispute will, by written notice to the other, have
such dispute referred to their respective executive officers designated below or
their successors, for


                                       33.
<PAGE>

attempted resolution by good faith negotiations within fourteen (14) days after
such notice is received.  Said designated officers are as follows:

          For Roche:          Head of the Pharma Division

          For Gilead:         Chief Executive Officer

     In the event the designated executive officers are not able to resolve such
dispute, either party may at any time after the 14 day period invoke the
provisions of Section 14.2 hereinafter.

     14.2 ALTERNATIVE DISPUTE RESOLUTION.  Following settlement efforts pursuant
to Section 14.1, any dispute, controversy or claim arising out of or relating to
the validity, construction, enforceability or performance of this Agreement,
including disputes relating to alleged breach or to termination of this
Agreement under Section 9.3, other than disputes which are expressly prohibited
herein from being resolved by this mechanism, shall be settled by binding
Alternative Dispute Resolution ("ADR") in the manner described below:

               (a)  ADR REQUEST.  If a party intends to begin an ADR to resolve
a dispute, such party shall provide written notice (the "ADR Request") to
counsel for the other party informing such other party of such intention and the
issues to be resolved.  From the date of the ADR Request and until such time as
any matter has been finally settled by ADR, the running of the time periods
contained in Section 9.3 as to which party must cure a breach of this Agreement
shall be suspended as to the subject matter of the dispute.

               (b)  ADDITIONAL ISSUES.  Within ten (10) business days after the
receipt of the ADR Request, the other party may, by written notice to the
counsel for the party initiating ADR, add additional issues to be resolved.

               (c)  NO ADR OF PATENT ISSUES.  Disputes regarding the scope,
validity and enforceability of patents shall not be subject to this Section
14.2, and shall be submitted to a court of competent jurisdiction.

     14.3 ARBITRATION PROCEDURE.  The ADR shall be conducted pursuant to the
ENDISPUTE Rules then in effect, except that notwithstanding those rules, the
following provisions shall apply to the ADR hereunder:

               (a)  ARBITRATOR.  The arbitration shall be conducted by a panel
of three arbitrators (the "Panel").  The Panel shall be selected from a pool of
retired independent federal judges to be presented to the parties by ENDISPUTE.


                                       34.
<PAGE>


               (b)  PROCEEDINGS.  The time periods set forth in the ENDISPUTE
rules shall be followed, unless a party can demonstrate to the Panel that the
complexity of the issues or other reasons warrant the extension of one or more
of the time tables.  In such case, the Panel may extend such time tables, but in
no event shall the time tables being extended so that the ADR proceeding extends
more than 18 months from its beginning to the Award.  In regard to such time
tables, the parties (i) acknowledge that the issues that may arise in any
dispute involving this Agreement may involve a number of complex matters and
(ii) confirm their intention that each party will have the opportunity to
conduct complete discovery with respect to all material issues involved in a
dispute within the framework provided above.  Within such time frames, each
party shall have the right to conduct discovery in accordance with the Federal
Rules of Civil Procedure.  The Panel shall not award punitive damages to either
party and the parties shall be deemed to have waived any right to such damages.
The Panel shall, in rendering its decision, apply the substantive law of the
State of California, without regard to its conflict of laws provisions, except
that the interpretation of and enforcement of this Section 14.3(b) shall be
governed by the Federal Arbitration Act.  The Panel shall apply the Federal
Rules of Evidence to the hearing.  The proceeding shall take place in the City
of New York.  The fees of the Panels and  ENDISPUTE shall be paid by the losing
Party which shall be designated by the Panel.  If the Panel is unable to
designate a losing party, it shall so state and the fees shall be split equally
between the parties.

               (c)  AWARD. The Panel is empowered to award any remedy allowed by
law, including money damages, multiple damages, prejudgment interest and
attorneys' fee, and to grant final, complete, interim, or interlocutory relief,
including injunctive relief but excluding punitive damages.

               (d)  COSTS. Except as set forth in Section 14.3(b), above, each
party shall bear its own legal fees.  The Panel shall assess its costs, fees and
expenses against the party losing the ADR unless it believes that neither party
is the clear loser, in which case the Panel shall divide such fees, costs and
expenses according to the Panel's sole discretion.

               (e)  CONFIDENTIALITY.  The ADR proceeding shall be confidential
and the Panel shall issue appropriate protective orders to safeguard each
party's Proprietary Information.  Except as required by law, no party shall make
(or instruct the Panel to make) any public  announcement with respect to the
proceedings or decision of the Panel without prior written consent of each other
party.  The existence of any dispute submitted to ADR, and the award, shall be
kept in confidence by the parties and the Panel, except as required in
connection with the enforcement of such award or as otherwise required by
applicable law.


                                       35.
<PAGE>

     14.4 JUDICIAL ENFORCEMENT.  The parties agree that judgment on any arbitral
award issued pursuant to this Article 14 shall be entered in the United States
District Court for the Northern District of California or, in the event such
court does not have subject matter jurisdiction over the dispute in question,
such judgment shall be entered in the Superior Court of the State of California,
in the County of San Mateo.

     14.5 GOVERNING LAW.  This Agreement is made in accordance with and shall be
governed and construed under the laws of the State of California, as such laws
are applied to contract entered into and to be performed within such state.

                                   ARTICLE 15

                                  MISCELLANEOUS

     15.1 AGENCY.  Neither party is, nor will be deemed to be, an employee,
agent or legal representative of the other party for any purpose.  Neither party
will be entitled to enter into any contracts in the name of, or on behalf of the
other party, nor will a party be entitled to pledge the credit of the other
party in any way or hold itself out as having authority to do so.  This
Agreement is an arm's-length license agreement between the parties and shall not
constitute or be construed as a joint venture.

     15.2 ASSIGNMENT.  Except as otherwise provided herein, neither this
Agreement nor any interest hereunder will be assignable in part or in whole by
any party without the prior written consent of the other; provided, however,
that either party may assign this Agreement to any of its Affiliates or to any
successor by merger or sale of all or substantially all of its business assets
to which this Agreement relates in a manner such that the assignor will remain
liable and responsible for the performance and observance of all its duties and
obligations hereunder.  This Agreement will be binding upon the successors and
permitted assigns of the parties and the name of a party herein will be deemed
to include the names of such party's successors and permitted assigns to the
extent necessary to carry out the intent of this Agreement.  Any assignment
which is not in accordance with this Section 15.2 will be void.

     15.3 AMENDMENT.  No amendment or modification hereof shall be valid or
binding upon the parties unless made in writing and signed by both parties.

     15.4 NOTICES.  Any notice or other communication required or permitted to
be given to either party hereto shall be in writing unless otherwise specified
and shall be deemed to have been properly given and to be effective on the date
of delivery if delivered in person or by facsimile or three (3) days after
mailing by registered or certified mail, postage paid, to the other party at the
following address:


                                       36.
<PAGE>

     In the case of Gilead:

          Gilead Sciences, Inc.
          353 Lakeside Drive
          Foster City, CA 94404
          Telephone: (415) 574-3000
          FAX: (415) 578-9264
          Attention: Chief Executive Officer

          AND

          Gilead Sciences, Inc.
          353 Lakeside Drive
          Foster City, CA 94404
          Telephone: (415) 574-3000
          Fax: (415) 572-6622
          Attention: General Counsel

     In the case of Roche:

          F. Hoffmann-La Roche Ltd
          CH-4070 Basel, Switzerland
          Telephone: 41-61-688 30 60
          FAX: 41-61-688 13 96
          Attention: Corporate Law Department

          AND

          Hoffmann-La Roche Inc.
          340 Kingsland Street
          Nutley, NJ   07110
          Telephone: (201) 235-2165
          FAX: (201) 235-3500
          Attention: Corporate Secretary

Either party may change its address for communications by a notice to the other
party in accordance with this Section 15.4.

     15.5 FORCE MAJEURE.  Any prevention, delay or interruption of performance
by any party under this Agreement shall not be considered a breach of this
Agreement if and to the extent caused by occurrences beyond the reasonable
control of the party affected, including but not limited to acts of God,
embargoes, governmental restrictions, strikes or


                                       37.
<PAGE>

other concerted acts of workers, fire, flood, earthquake, explosion, riots,
wars, civil disorder, rebellion or sabotage.  The party suffering such
occurrence shall immediately notify the other party and any time for performance
hereunder shall be extended by the actual time of prevention, delay, or
interruption caused by the occurrence.

     15.6 AFFILIATES.  The parties hereto acknowledge that Roche will carry out
many of the activities required or permitted pursuant to this Agreement through
its Affiliates.  Roche hereby represents and warrants to Gilead that this
Agreement shall be binding on its Affiliates and further guarantees the
performance of its Affiliates in accordance with this Agreement as if such
Affiliates were parties to this Agreement.  In the event either party to this
Agreement is acquired by another company, then the technology and programs of
the acquiring company in existence at the time of such transaction shall not be
subject to this Agreement.

     15.7 EXPORT CONTROL.  This Agreement is made subject to any restrictions
concerning the export of products or technical information from the United
States of America or other countries which may be imposed upon or related to
Gilead or Roche from time to time.  Each party agrees that it will comply with
all applicable export laws and regulations in connection with its activities
under this Agreement.

     15.8 SEVERABILITY.  If any term, condition or provision of this Agreement
is held to be unenforceable for any reason, it shall, if possible, be
interpreted, to achieve the intent of the parties to this Agreement to the
extent possible rather than voided.  If not capable of such interpretation, the
parties shall in good faith seek to agree on an alternative provision reflecting
the intent of the parties which is enforceable.  In any event, all other terms,
conditions and provision of this Agreement shall be deemed valid and enforceable
to the full extent.

     15.9 CUMULATIVE RIGHTS.  The rights, powers and remedies hereunder shall be
in addition to, and not in limitation of, all rights, powers and remedies
provided at law or in equity, or under any other agreement between the parties.
All of such rights, powers and remedies shall be cumulative, and may be
exercised successively or cumulatively.

     15.10     WAIVER.  No waiver by either party hereto on any breach or
default of any of the covenants or agreements herein set forth shall be deemed a
waiver as to any subsequent or similar breach or default.

     15.11     ENTIRE AGREEMENT.  This Agreement, and all Exhibits and Schedules
referred to herein, embody the entire understanding of the parties with respect
to the subject matter hereof and shall supersede all previous communications,
representations or understandings, either oral or written, between the parties
relating to the subject matter hereof.


                                       38.
<PAGE>

     IN WITNESS WHEREOF, the parties hereto have executed this Agreement by
their respective officer hereunto duly authorized.

GILEAD SCIENCES, INC.              F. HOFFMANN-LA ROCHE LTD



By: /s/ John C. Martin             By: /s/ W. Henrich
    -------------------------          ------------------------------
Name:   John C. Martin             Name: Werner Henrich
      -----------------------            ------------------------------
Title:  CEO                        Title:  Director
       ----------------------             ------------------------------

                                   HOFFMANN-LA ROCHE INC.

                                   By: /s/ Stephen Sulovar
                                       ---------------------------------
                                   Name: Stephen Sulovar
                                         -------------------------------
                                   Title:  Sr. Vice President
                                          ------------------------------




                                       39.

<PAGE>



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