Background Information on Fluconazole (Diflucan)
1999 Fluconazole generated $1.002 billion (US) in
global revenues. This represented about 1/16th of Pfizer's total revenues
for all products in 1999. In the US, fluconazole generated $480 million
in revenues; in international markets, fluconazole generated $522 million
1998 Fluconazole generated $916 million (US) in global
revenues. In the US, fluconazole generated $440 million in revenues; in
international markets, fluconazole generated $476 million in revenues.
Vaginal Candidiasis (vaginal yeast infections due to Candida).
Oropharyngeal and esophageal candidiasis.
| Patent Number
|| Date of Patent Filing
|| Date of Patent Approval
|| Patent Expiration
|| Imperial Chemical Industries
| Jun 2, 1981
|| Nov 22, 1983
|| Jun 02, 2001
|| Jun 1, 1982
|| Sep 13, 1983
|| Jan 29, 2004
Patent 4416682 was filed on June 2, 1981 and was approved
on November 22, 1983. The inventor was Paul A Worthington from Maidenhead,
Great Britain. US patent 4416682 was assigned to Imperial Chemical Industries
PLC (London, GB2). Imperial Chemical Industries (ICI) sold their pharmaceutical
division to AstraZeneca. According to the US FDA Orange Book, US patent 4416682
applies to the Diflucan formulation of fluconazole. ICI's specific claims to
fluconazole involve the 2,4-dichloro analogue of fluconazole. In addition, ICI claims
halogenated derivatives generically in US patent 4416682. Neither ICI or AstraZeneca manufacture fluconazole.
Patent 4404216 was filed on June 1, 1982 and was approved
on September 13, 1983. Although US patent 4404216 was filed one year later
than US patent 4416682, it was approved a little more than two months earlier.
The inventor was Kenneth Richardson from Canterbury, Great Britain. US patent
4404216 was assigned to Pfizer Inc. (New York, NY). Although the US FDA Orange Book lists
January 29, 2004 as the expiration of US patent 4404216, another source indicates that
the Waxman-Hatch extension for US patent 4404216 pushed the expiry date to July 3, 2005.
Corrections or suggestions to Thiru Balasubramaniam
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